Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism.
Aijun HouXiaoding XuYu ZhangHongxiu HeYihan FengWenhui FanRongrong TanLikun GongJing ChenPublished in: Liver international : official journal of the International Association for the Study of the Liver (2024)
We first demonstrated the relationship between miRNA dosage and NAFLD and proved that PA can activate the PRMT5-MDM2-Drosha signalling pathway to regulate miRNA biogenesis.
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