Non-invasive ventilation alternating with high-flow nasal oxygen versus high-flow nasal oxygen alone after extubation in COPD patients: a post hoc analysis of a randomized controlled trial.
Arnaud W ThilleRémi CoudroyMai-Anh NayArnaud GacouinMaxens DecavèleRomain SonnevilleFrançois BeloncleChristophe GiraultLaurence DangersAlexandre LautretteQuentin LevratAnahita RouzéEmmanuel VivierJean-Baptiste LascarrouJean-Damien RicardKeyvan RazaziGuillaume BarberetChristine LebertStephan EhrmannAlexandre MassriJeremy BourenneGael PradelPierre BaillyNicolas TerziJean DellamonicaGuillaume LacaveRené RobertStéphanie RagotJean-Pierre Fratnull nullPublished in: Annals of intensive care (2021)
In COPD patients, prophylactic NIV alternating with high-flow nasal oxygen significantly decreased the risk of reintubation compared with high-flow nasal oxygen alone. Trial registration The study was registered at http://www.clinicaltrials.gov with the trial registration number NCT03121482 (20 April 2017).