Multi-Omic Architecture of Obstructive Hypertrophic Cardiomyopathy.
Ramin GarmanyJ Martijn BosDavid J TesterJohn R GiudicessiCristobal G Dos RemediosSurendra DasariNagaswaroop K NagarajAsha A NairKenneth L JohnsonZachary C RyanJoseph J MaleszewskiSteven R OmmenJoseph A DearaniMichael J AckermanPublished in: Circulation. Genomic and precision medicine (2023)
At time of surgical myectomy, the ventricular proteome, independent of genotype, reveals widespread upregulation and activation of hypertrophy pathways, mainly involving the RAS-MAPK signaling cascade. In addition, there is a counterregulatory transcriptional downregulation of the same pathways. RAS-MAPK activation may serve a crucial role in hypertrophy observed in HCM.