The effect of botulinum toxin on ureteral inflammation.

Kevin KrughoffFaith L AndersonScott PalisoulAlison L YoungJason R PettusKaren L MoodieChristopher OgomoSteven S TauRachel A MosesMatthew C HavrdaDavid R Chavez

Published in: World journal of urology (2020)

We describe the feasibility of a novel in vivo model of ureteral inflammation and report the first histologic study of the effects of BoNT-A on the ureter. Preliminary findings show that BoNT-A attenuates ureteral PGE synthase expression under conditions of inflammation. The application of BoNT-A may provide anti-inflammatory and analgesic effects in the context of ureteral disorders.

Keyphrases

oxidative stress
botulinum toxin
anti inflammatory
editorial comment
poor prognosis
spinal cord injury
long non coding rna