Clinical Effect of Mirikizumab Treatment on Bowel Urgency in Patients with Moderately to Severely Active Ulcerative Colitis and the Clinical Relevance of Bowel Urgency Improvement for Disease Remission.
Marla C DubinskyDavid B ClemowTheresa Hunter GibbleXingyuan LiSeverine VermeireTadakazu HisamatsuSimon P L TravisPublished in: Crohn's & colitis 360 (2022)
In patients with ulcerative colitis, bowel urgency improvement was associated with better clinical outcomes than in patients without improvement during induction and maintenance. A greater proportion of mirikizumab patients achieved sustainable bowel urgency improvement and remission compared to placebo patients.