Spontaneous Facet Joint Osteoarthritis in NFAT1-Mutant Mice: Age-Dependent Histopathologic Characteristics and Molecular Mechanisms.

Jinxi Wang Qinghua Lu Matthew J Mackay Xiangliang Liu Yi Feng Douglas C BurtonMarc A Asher

Published in: The Journal of bone and joint surgery. American volume (2022)

This murine FJOA model resembles the features of human FJOA and may provide new insights into the pathogenesis of and therapeutic strategies for FJOA in humans.

Keyphrases

endothelial cells
wild type
rheumatoid arthritis
induced pluripotent stem cells
high fat diet induced
knee osteoarthritis
pluripotent stem cells
nuclear factor
immune response
metabolic syndrome
skeletal muscle
inflammatory response
insulin resistance
toll like receptor