Login / Signup

Dihydroartemisinin engages liver fatty acid binding protein and suppresses metastatic hepatocellular carcinoma growth.

Mei-Ling RuanYungen LiuChunlei ZhangXiaowen MaoDi HuChun-Nam LokJudy Wai Ping YamChi-Ming Che
Published in: Chemical communications (Cambridge, England) (2023)
Dihydroartemisinin non-covalently binds liver fatty acid binding protein (FABP1) with micromolar affinity, acts as a FABP1-dependent peroxisome proliferator-activated receptor alpha agonist and inhibits metastatic hepatocellular carcinoma growth.
Keyphrases
  • binding protein
  • fatty acid
  • squamous cell carcinoma
  • small cell lung cancer
  • signaling pathway