Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects.
Vadim OsadchiyJennifer S LabusArpana GuptaJonathan JacobsCody Ashe-McNalleyElaine Y HsiaoEmeran A MayerPublished in: PloS one (2018)
The findings support the hypothesis that gut microbiota-derived indole metabolites may influence hedonic food intake and obesity by acting on the extended reward network, specifically the amygdala-nucleus accumbens circuit and the amygdala-anterior insula circuit. These cross sectional, data-driven results provide valuable information for future mechanistic studies.
Keyphrases
- functional connectivity
- resting state
- prefrontal cortex
- cross sectional
- ms ms
- metabolic syndrome
- insulin resistance
- type diabetes
- weight loss
- current status
- weight gain
- high fat diet induced
- case control
- health information
- healthcare
- white matter
- skeletal muscle
- multiple sclerosis
- temporal lobe epilepsy
- physical activity