In vitro efficacy of gentamicin released from collagen sponge in eradication of bacterial biofilm preformed on hydroxyapatite surface.
Beata MaczynskaAnna SecewiczDanuta SmutnickaPatrycja SzymczykRuth Dudek-WicherAdam F JunkaMarzenna BartoszewiczPublished in: PloS one (2019)
Biofilm-related infections of bones pose a significant therapeutic issue. In this article we present in vitro results of the efficacy of gentamicin released from a collagen sponge carrier against Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae biofilms preformed on hydroxyapatite surface. The results indicate that high local concentrations of gentamicin released from a sponge eradicate the biofilm formed not only by gentamicin-sensitive strains but, to some extent, also by those that display a resistance pattern in routine diagnostics. The data presented in this paper is of high clinical translational value and may find application in the treatment of bone infections.
Keyphrases
- pseudomonas aeruginosa
- staphylococcus aureus
- biofilm formation
- klebsiella pneumoniae
- candida albicans
- escherichia coli
- tissue engineering
- cystic fibrosis
- bone regeneration
- multidrug resistant
- bone mineral density
- electronic health record
- wound healing
- clinical practice
- big data
- combination therapy
- drug resistant
- machine learning
- artificial intelligence
- lactic acid
- postmenopausal women