The type 1 interferon signature reflects multiple phenotypic and activity measures in dermatomyositis.
Mika M TabataLuqman Mushila HodgkinsonTiffany T WuShufeng LiChristine HuardShanrong ZhaoDonald BennettJillian JohnsonCassandra TierneyWen HeJanet E BuhlmannKaren M PageKristen JohnsonLivia A Casciola-RosenLorinda ChungKavita Y SarinDavid FiorentinoPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2023)
The IFN1 score independently associates with both skin and muscle disease activity as well as certain clinical and serologic features in DM. Accounting for the effect of muscle disease and anti-MDA5 status reveals that the IFN1 score is strongly correlated with skin disease activity and provides support for IFN1 blockade as a therapeutic strategy for DM. This article is protected by copyright. All rights reserved.