Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease.
Alexey A ShadrinSören MuchaDavid EllinghausMary B MakariousCornelis BlauwendraatAshwin A K SreelathaAntonio Heras-GarvinJinhui DingMonia HammerAlexandra Foubert-SamierWassillios G MeissnerOlivier RascolAnne Pavy-Le TraonOleksandr FreiKevin S O'ConnellShahram BahramiStefan SchreiberWolfgang LiebMartina Müller-NurasyidUlf SchminkeGeorg HomuthCarsten O SchmidtMarkus M NöthenPer HoffmannChristian GiegerGregor Wenningnull nullJ Raphael GibbsAndre FrankeJohn HardyNadia StefanovaThomas GasserAndrew SingletonHenry HouldenSonja W ScholzOle A AndreassenManu SharmaPublished in: Movement disorders : official journal of the Movement Disorder Society (2020)
Our study provides evidence of shared genetic etiology between MSA and inflammatory bowel disease with an important role of the C7 gene in both phenotypes, with the implication of immune and gut dysfunction in MSA pathophysiology. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.