Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis.

John P ReillyFan WangTiffanie K JonesJessica A PalakshappaBrian J AndersonMichael G S ShashatyThomas G DunnErik D JohanssonThomas R RileyBrian LimJason AbbottCaroline A G IttnerEdward CantuXihong LinCarmen MikacenicMark M WurfelDavid C ChristianiCarolyn S CalfeeMichael A MatthayJason D ChristieRui FengNuala J Meyer

Published in: Intensive care medicine (2018)

In septic European ancestry subjects, the strongest ANG2-determining ANGPT2 genetic variant is associated with higher ARDS risk. Plasma ANG2 may be a causal factor in ARDS development. Strategies to reduce plasma ANG2 warrant testing to prevent or treat sepsis-associated ARDS.

Keyphrases

acute respiratory distress syndrome
mechanical ventilation
extracorporeal membrane oxygenation
angiotensin ii
acute kidney injury
intensive care unit
septic shock
dna methylation
gene expression
social support
depressive symptoms