BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia.

Xu SangYongping ZhangFang FangLi GaoYanfang TaoXiaolu LiZimu ZhangJianwei WangYuanyuan TianZhiheng LiDi YaoYumeng WuXinran ChuKunlong ZhangLi MaLihui LuYanling ChenJuanjuan YuRan ZhuoShuiyan WuZhen ZhangJian Pan Shao-Yan Hu

Published in: Journal of immunology research (2022)

GNE-987 had strong antitumor activity in AML. GNE-987 could effectively inhibit the expression of SE-related oncogenes including LYL1 in AML. Our results suggested that GNE-987 had broad prospects in the treatment of AML.

Keyphrases

acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
poor prognosis
binding protein
genome wide
copy number
acute lymphoblastic leukemia
drug induced
smoking cessation