On the effect of dose delivery temporal domain on the biological effectiveness of central nervous system CyberKnife radiosurgery applications: theoretical assessment using the concept of biologically effective dose.

, between 21 and 50 min, this can be expressed byBEDslr(Gy2.47)=-0.35±2.8%∙Tmin+(76.74±0.4%).Compared to the acute exposure approach, a BED 'loss' of 21% is associated with the delivery of 13 Gy to the VS-tumor in 35 min.