The relationship between blood-brain barrier dysfunction and neurocognitive impairments in first-episode psychosis: findings from a retrospective chart analysis.
Isabel MaurusSarah WagnerMattia CampanaLukas RoellJohanna StraussPiyumi FernandoSusanne MuenzPeter EichhornAndrea SchmittSusanne KarchOliver PogarellRolf R EngelPeter FalkaiAlkomiet HasanElias WagnerPublished in: BJPsych open (2023)
The hypothesised relationship between BBB and neurocognitive impairments was not detectable in our retrospective cohort. Further cerebrospinal fluid-based studies with a longitudinal assessment of cognitive functioning and disease trajectory are urgently needed.