Polysaccharides from Dendrobium officinale improve obesity-induced insulin resistance through the gut microbiota and the SOCS3-mediated insulin receptor substrate-1 signaling pathway.
Wei JiangJin TanJiacheng ZhangXin DengXinyue HeJin ZhangTong LiuRong SunMengxun SunKuo ChenTingjia XuYuling YanAli MoazzamiE-Jiao WuJiasui ZhanBinhong HuPublished in: Journal of the science of food and agriculture (2023)
Dendrobium officinale polysaccharide regulated the gut microbiota, enhanced IRS-1 expression, and mitigated liver injury and insulin resistance due to a high-fat diet. These findings depict the potential anti-insulin resistance properties of DOP and offer further evidence for addressing obesity and its complications. © 2023 Society of Chemical Industry.
Keyphrases
- insulin resistance
- high fat diet
- liver injury
- drug induced
- type diabetes
- adipose tissue
- high fat diet induced
- metabolic syndrome
- skeletal muscle
- polycystic ovary syndrome
- signaling pathway
- glycemic control
- poor prognosis
- high glucose
- risk factors
- diabetic rats
- transcription factor
- binding protein
- endothelial cells
- cell proliferation
- oxidative stress
- climate change