Sodium absorption stimulator prostasin (PRSS8) has an anti-inflammatory effect via downregulation of TLR4 signaling in inflammatory bowel disease.

Yoshihiko SugitaniAtsushi NishidaOsamu InatomiMasashi OhnoTakayuki ImaiMasahiro KawaharaKenichiro KitamuraAkira Andoh

Published in: Journal of gastroenterology (2020)

Prostasin has an anti-inflammatory effect via downregulation of TLR4 expression in colonic epithelial cells. Reduced prostasin expression in IBD mucosa is linked to the deterioration of local anti-inflammatory activity and may contribute to the persistence of mucosal inflammation.

Keyphrases

anti inflammatory
poor prognosis
toll like receptor
inflammatory response
immune response
cell proliferation
ulcerative colitis
signaling pathway
oxidative stress
nuclear factor