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A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic Th17 Response in Primary Sjögren Syndrome.

Yuzhou GanHaotian ZhouYixue GuoBo HuangHongjiang LiuZiye WangZijun LiXiaozhen ZhaoHuaqun ZhuQimao HanHua YeJing HeQingwen WangZhanguo LiXiaolin Sun
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
Our results identified the pathogenic role of GITRL in exacerbating disease activity and promoting pathogenic Th17 response in pSS through a GITRL-mTORC1-GM-CSF loop. These findings suggest GITRL might be a promising therapeutic target in the treatment of pSS.
Keyphrases
  • disease activity
  • rheumatoid arthritis
  • systemic lupus erythematosus
  • rheumatoid arthritis patients
  • ankylosing spondylitis
  • juvenile idiopathic arthritis
  • transcription factor
  • combination therapy