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Overcoming resistance to αPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of αCTLA-4 and αPD-1 blockers.

Laetitia Nebot-BralAntoine HollebecqueAndrey A YurchenkoLouise de ForcevilleMathieu DanjouJean-Mehdi JouniauxReginaldo C A RosaCaroline PouvelleSaid AoufouchiPerrine VuagnatCristina SmolenschiEmeline ColombaAlexandra LearyAurélien MarabelleJean-Yves ScoazecLydie CassardSergey NikolaevNathalie ChaputPatricia L Kannouche
Published in: Journal for immunotherapy of cancer (2022)
TIN countered αPD-1 efficacy in MMRD tumors. Since αCTLA-4 could restrict TIN accumulation, αPD-1+αCTLA-4 combination overcomes αPD-1 resistance in hosts with hypermutated MMRD tumors displaying abnormal neutrophil accumulation.
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