Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA.
Neeraj AgarwalSumanta K PalAndrew W HahnRoberto H NussenzveigGregory R PondSumati V GuptaJue WangMehmet A BilenGurudatta NaikPooja GhataliaChristopher J HoimesDharmesh GopalakrishnanPedro C BarataAlexandra DrakakiBishoy M FaltasLesli A KiedrowskiRichard B LanmanRebecca J NagyNicholas J VogelzangKenneth M BoucherUlka N VaishampayanGuru SonpavdePetros GrivasPublished in: Cancer (2018)
Among patients with mUC for whom no tumor tissue was available, cfDNA NGS was able to identify a similar profile of GAs for biomarker-driven clinical trials compared with tumor tissue. Despite the more aggressive clinical course, cases of mUTUC demonstrated a circulating tumor DNA genomic landscape that was similar to that of mLTUC. Cancer 2018;124:2115-24. © 2018 American Cancer Society.