Identification of glycogen phosphorylase L as a potential target for lung cancer.
Xin-Ling HeWen-Yu LyuXin-Yuan LiHong ZhaoLu QiJin-Jian LuPublished in: Medical oncology (Northwood, London, England) (2023)
Traditional Chinese medicine (TCM) has been widely used for cancer treatment. Identification of anti-cancer targets of TCM is the first and principal step in discovering molecular mechanisms of TCM as well as obtaining novel targets for cancer therapy. In this study, glycogen phosphorylase L (PYGL) was identified as one of the targeted proteins for several TCMs and was upregulated in various cancer types. The expression level of PYGL was positively correlated with the stage of lung cancer and the poor prognosis of patients. Meanwhile, knockdown of PYGL significantly inhibited proliferation and migration in lung cancer cells. In addition, PYGL was associated with spindle, kinetochore, and microtubule, the cellular components that are closely related to mitosis, in lung cancer. Moreover, PYGL was more susceptible to be upregulated by 144 mutated genes. Taken together, PYGL is a potential target for lung cancer treatment and its molecular mechanism probably influences the mitotic function of cells by regulating energy metabolism.
Keyphrases
- poor prognosis
- cancer therapy
- long non coding rna
- end stage renal disease
- bioinformatics analysis
- newly diagnosed
- ejection fraction
- induced apoptosis
- chronic kidney disease
- prognostic factors
- genome wide
- peritoneal dialysis
- gene expression
- human health
- endoplasmic reticulum stress
- dna methylation
- drug induced
- cell cycle arrest
- transcription factor
- binding protein
- young adults
- climate change
- signaling pathway