Airway gene expression identifies subtypes of type 2 inflammation in severe asthma.

Laurits FrøssingAlexander SilberbrandtAnna Von BülowDitte Kjaersgaard KleinMarcus Ross ChristensenVibeke BackerKatherine J BainesCeleste Porsbjerg

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)

Clustering of airway mRNA expression identified five molecular clusters of severe asthma of which three were considered T2 high. Co-expression of IL-5- and IL-13-related genes at moderate levels was present in almost half of patients, while marked elevated expression of both was rare. In contrast to IL-5, clusters with isolated IL-13- and Th1/Th17-related gene expression were not identified.

Keyphrases

gene expression
poor prognosis
dna methylation
end stage renal disease
ejection fraction
oxidative stress
newly diagnosed
single cell
rna seq