Association of Baseline Factors With Glycemic Outcomes in GRADE: A Comparative Effectiveness Randomized Clinical Trial.
W Timothy GarveyRobert M CohenNicole M ButeraErin J KazemiNaji YounesSamuel P RosinColleen E SurattAndrew J AhmannPriscilla A HollanderJonathan KrakoffCatherine L MartinElizabeth R SeaquistMichael W SteffesJohn M Lachinnull nullPublished in: Diabetes care (2024)
Several baseline factors were associated with the glycemic outcome but not with differential effectiveness of the four medications. Failure to maintain HbA1c <7% was largely driven by younger age and higher HbA1c at baseline. Factors that predict earlier glycemic deterioration could help in targeting patients for more aggressive management.