Succinic acid exacerbates experimental autoimmune uveitis by stimulating neutrophil extracellular traps formation via SUCNR1 receptor.

Hongxi LiHandan TanZhangluxi LiuSu PanShiyao TanYunyun ZhuQingfeng WangGuannan SuChunjiang ZhouQingfeng CaoPeizeng Yang

Published in: The British journal of ophthalmology (2022)

Succinic acid could worsen EAU induced by IRBP in mice. This effect was possibly mediated by its upregulation on NETs generation and frequencies of Th1/Th17 cells in affiliation with increased production of IFN-γ/IL-17A through succinic acid-SUCNR1 axis.

Keyphrases

induced apoptosis
multiple sclerosis
cell proliferation
immune response
type diabetes
dendritic cells
poor prognosis
systemic lupus erythematosus
high fat diet induced
binding protein
drug induced
wild type