Association of in utero HIV exposure with child brain structure and language development: a South African birth cohort study.
Catherine J WedderburnShunmay YeungSivenesi SubramoneyJean-Paul FoucheShantanu H JoshiKatherine L NarrAndrea M RehmanAnnerine RoosDiana M GibbHeather J ZarDan J SteinKirsten A DonaldPublished in: BMC medicine (2024)
In this cohort study, exposure to HIV during pregnancy was associated with altered cortical structure in early life. Our findings indicate that differences in cortical thickness development in the prefrontal region in children who are HEU may be a pathway leading to language impairment. Longitudinal studies are needed to determine the lasting impact.
Keyphrases
- early life
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- autism spectrum disorder
- men who have sex with men
- young adults
- mental health
- working memory
- optical coherence tomography
- cross sectional
- functional connectivity
- transcranial magnetic stimulation
- multiple sclerosis
- cerebral ischemia
- case control
- subarachnoid hemorrhage