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Blood Markers of Inflammation, Neurodegeneration, and Cardiovascular Risk in Early Parkinson's Disease.

Michael BartlMohammed DaknaSebastian SchadeBirgit OtteTamara WickeElisabeth LangMaritta StarkeJens EbentheuerSandrina WeberKarl ToischerMoritz SchnelleFriederike Sixel-DöringClaudia TrenkwalderBrit Mollenhauer
Published in: Movement disorders : official journal of the Movement Disorder Society (2022)
We identified and validated possible PD plasma biomarker candidates for state, fate, and disease progression, elucidating new molecular processes with reduced endothelial/atherosclerotic processes, increased thromboembolic risk, and neuroinflammation. Further investigations and validation in independent and larger longitudinal cohorts are needed. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
  • oxidative stress
  • traumatic brain injury
  • endothelial cells
  • lipopolysaccharide induced
  • lps induced
  • cross sectional
  • atrial fibrillation
  • cognitive impairment
  • systematic review
  • inflammatory response