Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.

Jacki E Heraud-FarlowAlistair M ChalkSandra E LinderQin LiScott TaylorJoshua M WhiteLokman PangBrian J LiddicoatAnkita GupteJin Billy LiCarl R Walkley

Published in: Genome biology (2017)

These analyses demonstrate that the lifetime absence of ADAR1-editing is well tolerated in the absence of MDA5. We conclude that protein recoding arising from ADAR1-mediated editing is not essential for organismal homeostasis. Additionally, the phenotypes associated with loss of ADAR1 are the result of RNA editing and MDA5-dependent functions.

Keyphrases

crispr cas
breast cancer cells
protein protein
binding protein
signaling pathway
cell death