Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment.
Marina Roy-LuzarragaLouise E ReynoldsBeatriz de Luxán-DelgadoOscar MaiquesLaura WisniewskiEmma NewportVinothini RajeeveRebecca J G DrakeJesús Gómez-EscuderoFrances M RichardsCéline WellerChristof DormannYa-Ming MengPeter B VermeulenDieter SaurVictoria Sanz-MorenoPing-Pui WongCyrill GéraudPedro Rodriguez CutillasKairbaan M Hodivala-DilkePublished in: Cancer research (2022)
These findings establish the potential utility of combinatorial endothelial cell FAK targeting together with gemcitabine in future clinical applications to control metastasis in patients with pancreatic ductal adenocarcinoma.