Amexanthomycins A-J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA.
Xiaomei LiXingkang WuJing ZhuYue-Mao ShenPublished in: Applied microbiology and biotechnology (2017)
Ten new pentangular polyphenols, namely amexanthomycins A-J (1-10) were isolated from the strain Amycolatopsis mediterranei S699∆rifA constructed by deleting the polyketide synthase genes responsible for the biosynthesis of rifamycins. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data and high-resolution ESIMS. Amexanthomycins A-C (1-3) showed inhibitory activity against human DNA topoisomerases.
Keyphrases
- high resolution
- endothelial cells
- mass spectrometry
- molecular docking
- circulating tumor
- wastewater treatment
- electronic health record
- induced pluripotent stem cells
- genome wide
- cell free
- single molecule
- magnetic resonance
- big data
- pluripotent stem cells
- high speed
- tandem mass spectrometry
- cell wall
- machine learning
- genome wide identification
- genome wide analysis
- data analysis
- nucleic acid
- liquid chromatography