The evolution of patient-specific precision biomarkers to guide personalized heart-transplant care.

Mario C Deng
Published in: Expert review of precision medicine and drug development (2020)
This novel complementary non-invasive heart transplant monitoring strategy based on leukocyte gene expression profiling and donor-derived cell-free DNA that incorporates longitudinal variability measures provides an exciting novel algorithm of heart transplant allograft monitoring. This algorithm's clinical utility will need to be tested in an appropriately designed randomized clinical trial which is in preparation.