The CSF Profile Linked to Cortical Damage Predicts Multiple Sclerosis Activity.

Roberta MagliozziAntonio ScalfariAnna Isabella PisaniStefano ZiccardiDamiano MarastoniFrancesca Benedetta PizziniAlbulena BajramiAgnese TamantiMaddalena GuandaliniSamuele BonomiStefania RossiValentina MazziottiMarco CastellaroStefania MontemezziSarah RasiaRuggero CapraMarco PitteriChiara RomualdiRichard ReynoldsMassimiliano Calabrese

Published in: Annals of neurology (2020)

A specific CSF profile, mainly characterized by elevated levels of B-cell related cytokines, distinguishes patients at high risk of disease activity and severe cortical damage. The CSF analysis may allow stratifications of patients at diagnosis for optimizing therapeutic approaches. ANN NEUROL 2020;88:562-573.

Keyphrases

disease activity
multiple sclerosis
rheumatoid arthritis
systemic lupus erythematosus
end stage renal disease
rheumatoid arthritis patients
oxidative stress
newly diagnosed
ankylosing spondylitis
prognostic factors
juvenile idiopathic arthritis
early onset
peritoneal dialysis
cerebrospinal fluid
white matter