Adjuvant Chemoradiotherapy Associated with Improved Overall Survival in Resected Esophageal Squamous Cell Carcinoma after Neoadjuvant Chemoradiotherapy in Intensity-Modulated Radiotherapy Era.
Wing-Keen YapMing-Chieh ShihYu-Chen ChangChia-Hsin LinShih-Ming HuangTsung-You TsaiChing-Fu ChangChih-Chung HsuChen-Kan TsengMiao-Fen ChenDin-Li TsanChi-Ting LiauMing-Mo HouYin Kai ChaoChien-Hung ChiuTsung-Min HungPublished in: Biomedicines (2022)
This study demonstrated that adjuvant CRT was independently associated with a significantly improved survival and lower risk of recurrence than observation in esophageal squamous cell carcinoma patients staged as ypT3 and/or ypN+ after receiving neoadjuvant chemoradiotherapy and radical surgery. The results of this study have implications for the design of future clinical trials and may improve treatment outcomes of patients in this setting who cannot afford or are without access to adjuvant nivolumab.
Keyphrases
- locally advanced
- rectal cancer
- end stage renal disease
- early stage
- clinical trial
- ejection fraction
- lymph node
- newly diagnosed
- chronic kidney disease
- squamous cell carcinoma
- minimally invasive
- peritoneal dialysis
- radiation therapy
- heart failure
- randomized controlled trial
- free survival
- coronary artery bypass
- percutaneous coronary intervention
- double blind
- left ventricular
- surgical site infection