Lipidomic landscape of circulating extracellular vesicles isolated from adolescents exposed to ethanol intoxication: a sex difference study.
Carla Perpiñá-ClériguesSusana MelladoJosé F Català-SenentFrancesc IbáñezPilar CostaMiguel MarcosConsuelo GuerriFrancisco García-GarcíaConsuelo GuerriPublished in: Biology of sex differences (2023)
Our results suggest that binge ethanol drinking in human female adolescents leads to a higher content of plasma EV lipid species associated with EV biogenesis and the propagation of neuroinflammatory responses than in males. In addition, we discovered greater differences in lipid abundance between sexes in WT mice compared to TLR4-KO mice. Our findings also support the potential use of EV-enriched lipids as biomarkers of ethanol-induced neuroinflammation during adolescence.
Keyphrases
- young adults
- physical activity
- high fat diet induced
- fatty acid
- endothelial cells
- depressive symptoms
- high glucose
- inflammatory response
- traumatic brain injury
- diabetic rats
- induced pluripotent stem cells
- lipopolysaccharide induced
- skeletal muscle
- brain injury
- antibiotic resistance genes
- blood brain barrier
- metabolic syndrome
- human health
- subarachnoid hemorrhage
- wastewater treatment
- adipose tissue