Depression is associated with increased disease activity in patients with ulcerative colitis: A propensity score-matched analysis using a nationwide database in Japan.
Hideaki OyamaRintaro MoroiKunio TarasawaYusuke ShimoyamaTakeo NaitoAtsushi SakumaHisashi ShigaYoichi KakutaKiyohide FushimiKenji FujimoriYoshitaka KinouchiAtsushi MasamunePublished in: JGH open : an open access journal of gastroenterology and hepatology (2022)
Our study demonstrated an association between a worse clinical course of UC and depression. Although this result indicates that depression might be associated with increased disease activity in patients with UC, the causal relationship is still unclear. Further prospective studies are warranted.