Mitochondrial respiratory capacity remains stable despite a comprehensive and sustained increase in insulin sensitivity in obese patients undergoing gastric bypass surgery.
M T LundS LarsenM HansenJ CourraudA K FloydM StøckelJ W HelgeFlemming DelaPublished in: Acta physiologica (Oxford, England) (2018)
Among obese patients with and without type 2 diabetes undergoing RYGB surgery, intrinsic mitochondrial respiratory capacity in skeletal muscle is not correlated with insulin sensitivity before or after the surgical intervention. Mitochondrial respiratory function may not be germane to the pathophysiology and/or aetiology of obesity and/or type 2 diabetes.
Keyphrases
- obese patients
- gastric bypass
- type diabetes
- roux en y gastric bypass
- weight loss
- bariatric surgery
- insulin resistance
- minimally invasive
- oxidative stress
- skeletal muscle
- glycemic control
- coronary artery bypass
- patients undergoing
- randomized controlled trial
- cardiovascular disease
- metabolic syndrome
- respiratory tract
- adipose tissue
- surgical site infection
- high fat diet induced