Metastatic non-small-cell lung cancer without driver mutations: projections by therapy line in Western Europe, 2021-2026.
Xinmei ZhuLaura L DurbinGena KanasKelesitse PhiriKatie KeevenOtavio ClarkKnar NersesyanAmine AziezAlexander StojadinovicKelly F BellPublished in: Future oncology (London, England) (2023)
Aim: To estimate the incidence, prevalence and treated prevalence by line of therapy (LOT) for non-small-cell lung cancer (NSCLC) patients without driver mutations from 2021 to 2026. Materials & methods: Country-specific registry data for Western Europe were used to project incidence and prevalence of NSCLC; LOT information was obtained from CancerMPact ® Treatment Architecture physician surveys. Results: Incidence, prevalence and treated prevalence across LOTs for NSCLC are projected to increase across five WE countries, including for Stage IV patients without driver mutations (184,966 cases [2021] to 197,925 [2026]). Pembrolizumab monotherapy is utilized by ∼50% of NSCLC patients with programmed death-ligand 1 expression ≥50%. Conclusion: Improved treatment options for NSCLC patients without known driver mutations are important for combating the projected increase in prevalence.
Keyphrases
- risk factors
- small cell lung cancer
- end stage renal disease
- newly diagnosed
- ejection fraction
- advanced non small cell lung cancer
- chronic kidney disease
- primary care
- peritoneal dialysis
- healthcare
- clinical trial
- mesenchymal stem cells
- south africa
- deep learning
- poor prognosis
- brain metastases
- social media
- replacement therapy
- double blind