IL-10 and IL-17 expression by CD4+ T cells is altered in corticosteroid refractory immune thrombocytopenia (ITP).
Madeleine L StimpsonPhilippa J P LaitLauren P Schewitz-BowersEmily L WilliamsKimberley F ThirlwallRichard W J LeeCharlotte Ann BradburyPublished in: Journal of thrombosis and haemostasis : JTH (2020)
There is a relative abrogation of IL-10 and persistence of IL-17 expression in the CD4+ T cells of patients who clinically fail corticosteroid therapy. This observation has potential to inform both our mechanistic understanding of the action of corticosteroids in the treatment of ITP, and as a biomarker for steroid refractory disease, with potential application across a range of hematological and nonhematological conditions.