Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development.
Fitzwilliam SeibertzTony RubioRobin SpringerFiona PoppMelanie RitterAiste LiutkuteLena BarteltLea StelzerFereshteh HaghighiJan PietrasHendrik WindelNúria Díaz I PedrosaMarkus RapediusYannic DöringRichard SolanoRobin HindmarshRunzhu ShiMalte TiburcyTobias BruegmannIngo KutschkaKatrin Streckfuß-BömekeGeorge KensahLukas CyganekWolfram H ZimmermannNiels VoigtPublished in: Cardiovascular research (2023)
Classical hallmarks of AF-associated remodelling were mimicked through TP of iPSC-aCM and aEHM. The use of the ultrafast f-Chrimson depolarizing ion channel allowed us to model the time-dependence of AF-associated remodelling in vitro for the first time. The observation of electrical remodelling with associated reversible contractile dysfunction offers a novel platform for human-centric discovery of antiarrhythmic therapies.
Keyphrases
- atrial fibrillation
- catheter ablation
- endothelial cells
- induced pluripotent stem cells
- high glucose
- left atrial
- oral anticoagulants
- left atrial appendage
- high throughput
- oxidative stress
- pluripotent stem cells
- heart failure
- skeletal muscle
- small molecule
- percutaneous coronary intervention
- stem cells
- diabetic rats
- coronary artery disease
- left ventricular
- drug induced
- electron transfer
- chemotherapy induced
- replacement therapy