Xenotransplantation of human intestine into mouse abdomen or subcutaneous tissue: Novel platforms for the study of the human enteric nervous system.
N NagyN MarsianoR S BrucknerM ScharlM J GutnickS YagelE ArcieroA M GoldsteinNahum Yehuda ShpigelPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2017)
Abdominal xenografts represent a novel model that supports the growth and development of fetal human intestine. This in vivo approach will be a useful method to study maturation of the ENS, the pathophysiology of neurointestinal diseases, and the long-term survival and functional differentiation of neuronal stem cells for the treatment of enteric neuropathies.