Efficacy and safety of TOMAC for treatment of medication-naïve and medication-refractory restless legs syndrome: A randomized clinical trial and meta-analysis.

Haramandeep SinghFiona C BakerJoseph OjileBahman AdlouViktoriia KolotovskaStephanie K RigotJonathan D Charlesworth

Published in: Sleep medicine (2024)

The present trial confirmed previous reports documenting efficacy and safety of TOMAC in refractory RLS and indicated similar effect sizes in refractory versus naïve subgroups. The meta-analysis demonstrated that TOMAC significantly improves RLS symptoms in naïve participants.

Keyphrases

systematic review
adverse drug
healthcare
clinical trial
study protocol
meta analyses
randomized controlled trial
phase iii
case report
physical activity
depressive symptoms
case control
electronic health record
drug induced