CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling.

Lixia GaoZhigang XuZheng HuangYan TangDonglin YangJiuhong HuangLeilei HeManran LiuZhongzhu ChenYong Teng

Published in: Journal of experimental & clinical cancer research : CR (2020)

These findings explore the critical role of lipid metabolism in apoptosis, providing new insights into the AMPK-ACC signaling axis in crosstalk between lipid metabolism and apoptosis in CPI-613 treatment.

Keyphrases

endoplasmic reticulum stress
oxidative stress
cell cycle arrest
cell death
skeletal muscle
fatty acid
smoking cessation