Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis.
Julia VullingsJuliana Priscila VagoClaire E J WaterborgRogier M ThurlingsMarije I KoendersPeter L E M van LentPeter M van der KraanFlávio Almeida AmaralFons A J van de LooPublished in: Journal of immunology research (2020)
sTyro3 in the synovial fluid of RA patients correlates with local inflammatory molecules and systemic disease activity. These findings suggest that the reduced negative control of cell activation by TAM receptors due to their shedding in the synovial fluid, mainly sTyro3, favoring joint inflammation in RA patients.
Keyphrases
- disease activity
- end stage renal disease
- rheumatoid arthritis
- newly diagnosed
- ejection fraction
- oxidative stress
- chronic kidney disease
- systemic lupus erythematosus
- peritoneal dialysis
- prognostic factors
- ankylosing spondylitis
- stem cells
- rheumatoid arthritis patients
- mesenchymal stem cells
- cell therapy
- patient reported