Maternal IgG impairs the maturation of offspring intrathymic IL-17-producing γδT cells: Implications for murine and human allergies.

Marília G de-OliveiraAline A L LiraFábio R SgnottoAmanda H S InoueLudimila S SantosBernardo Y NakamatsuAlberto J S DuarteMaria C Leite-de-Moraes Jefferson Russo Victor

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)

Together, our results reveal that IgG from potentially tolerant atopic mothers can influence offspring thymic IL-17-producing γδT cell maturation. Furthermore, we suggest that IgG is an unprecedented modulatory factor of murine and human γδT cells. These observations may support the future development of IgG-based immunoregulatory therapeutic strategies.

Keyphrases

endothelial cells
high fat diet
induced pluripotent stem cells
pluripotent stem cells
gene expression
body mass index
physical activity
type diabetes
pregnant women
genome wide
birth weight