Metformin: evidence from preclinical and clinical studies for potential novel applications in cardiovascular disease.
Adel DihoumGraham RenaEwan R PearsonChim C LangIfy R MordiPublished in: Expert opinion on investigational drugs (2023)
Metformin may have some cardiovascular benefit in patients with and without diabetes, however the majority of clinical trials were small and are before the use SGLT2 inhibitors and GLP1-RAs. Larger contemporary randomised trials with metformin evaluating its cardiovascular benefit are warranted.