Human IL-6, IL-17, IL-1β, and TNF-α differently regulate the expression of pro-inflammatory related genes, tissue factor, and swine leukocyte antigen class I in porcine aortic endothelial cells.
Hanchao GaoLu LiuYanli ZhaoHidetaka HaraPengfei ChenJia XuJia TangLing WeiZesong LiDavid K C CooperZhiming CaiLisha MouPublished in: Xenotransplantation (2017)
In conclusion, our data suggest that human IL-6, IL-17, IL-1β, and TNF-α significantly activate PAECs and are likely to promote inflammation and coagulation reaction in response to xenograft.