Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1.

Jonathan F ThomasMarco Igor Valencia-SánchezSimone TamburriSusan L GloorSamantha RustichelliVictoria Godínez-LópezPablo De IoannesRachel LeeStephen Abini-AgbomsonKristjan GretarssonJonathan M BurgAllison R HickmanLu SunSaarang GopinathHailey TaylorMatthew J MeinersMarcus A CheekWilliam RiceEvgeny NudlerChao LuMichael-Christopher KeoghDiego PasiniKarim-Jean Armache

Published in: bioRxiv : the preprint server for biology (2023)

We reveal the molecular mechanism of nucleosomal H2AK119Ub deubiquitination by human BAP1/ASXL1.

Keyphrases

structural basis
endothelial cells
induced pluripotent stem cells
genome wide
pluripotent stem cells
single cell
gene expression
amino acid