Prospective Observational Cohort Study of Tenecteplase Versus Alteplase in Routine Clinical Practice.
Steven J WarachAdrienne Nicole DulaTruman J MillingSamantha MillerLeigh AllenNathan D ZuckCollin MillerChristine A JesserLotika R MisraJefferson T MileyManzure MawlaMing-Chieh DingJohn A BertelsonAnnie Y TsuiJohn R JeffersonHolly M DavisonDarshan N ShahKent T EllingtonMatthew M PadrickAlan S NovaVivek R KrishnaLisa A DavisDavid PaydarfarPublished in: Stroke (2022)
Switching to tenecteplase in routine clinical practice in a 10-hospital network was associated with shorter door-to-needle time and door-in-door-out times, noninferior favorable clinical outcomes at discharge, and reduced hospital costs. Evaluation in larger, multicenter cohorts is recommended to determine if these observations generalize.