Effect of spermidine on long non-coding RNAs MALAT1 in a rotenone induced-rat model of Parkinson's disease.
Noha Mohamed BadaeDoaa Ali AbdelmonsifRania Gaber AlyAmira M OmarMai S ShoelaEman M OmarPublished in: Fundamental & clinical pharmacology (2024)
Our preliminary study supports the protective effect of spermidine on the activation of autophagy and its antioxidant properties. Part of the antioxidant activity is due to the inhibition of MALAT1. However, MALAT1 does not correlate with the spermidine-induced autophagy pathway.