Alpha-arrestins Aly1/Art6 and Aly2/Art3 regulate trafficking of the glycerophosphoinositol transporter Git1 and impact phospholipid homeostasis.
Benjamin P RobinsonSarah HawbakerAnnette ChiangEric M JordahlSanket AnaokarAlexiy NikiforovRay W BowmanPhilip ZieglerCeara K McAteeJana Patton-VogtAllyson F O'DonnellPublished in: Biology of the cell (2021)
To our knowledge, this is the first example of α-arrestin regulation of phosphatidyliniositol-3-phosphate levels. In future studies it will be exciting to determine if other α-arrestins similarly alter PI and PIPs to change the cellular landscape.