Antidepressant Effect of Ketamine on Inflammation-Mediated Cytokine Dysregulation in Adults with Treatment-Resistant Depression: Rapid Systematic Review.
Shiryn D SukhramGrozdena YilmazJianying GuPublished in: Oxidative medicine and cellular longevity (2022)
While the anti-inflammatory effects of ketamine modulate specific proinflammatory cytokines, its rapid antidepressant effect on TRD patients remains inconsistent. However, our study findings can provide a reliable basis for future research on how to improve systemic inflammatory immune disorders and mental health. We suggest that ketamine infusion may be part of a comprehensive treatment approach in TRD patients with elevated levels of depression-specific inflammatory biomarkers.
Keyphrases
- systematic review
- mental health
- oxidative stress
- end stage renal disease
- pain management
- major depressive disorder
- depressive symptoms
- newly diagnosed
- ejection fraction
- chronic kidney disease
- sleep quality
- peritoneal dialysis
- low dose
- randomized controlled trial
- physical activity
- current status
- mental illness
- quantum dots